Epolones: Novel Sesquiterpene-Tropolones from Fungus OS-F69284 That Induce Erythropoietin in Human Cells
- 30 May 1998
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 61 (6) , 791-795
- https://doi.org/10.1021/np9800506
Abstract
In the course of our screening for small molecule modulators of erythropoietin gene expression, two novel sesquiterpene tropolones and pycnidone were isolated from a culture of OS-F69284 (ATCC 74390). Their structures were elucidated by extensive 1H and 13C NMR spectroscopic studies and chemical reactions. These compounds induced erythropoietin gene expression 5-fold at a concentration of 1−1.6 μM.Keywords
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