This paper presents further observations on the treatment of herpes zoster ophthalmicus with corticotropin and corticosteroids. In a previous paper Scheie and Alper1 reported the results obtained by the use of corticotropin and cortisone in 11 patients, 10 of whom showed complete recovery. The present report summarizes the treatment and course of 25 more patients with herpes zoster ophthalmicus who have been treated with hormones given systemically. All of the patients had typical cutaneous changes accompanied by ocular involvement and severe pain. Further experience has strengthened our initial conclusion that hormones exert a favorable influence when used therapeutically for herpes zoster ophthalmicus. Relief of pain usually is achieved in one or two days, and the ocular lesions show prompt improvement. The course of the skin lesions seems shortened. Several reports on the use of corticotropin and corticosteroids have appeared since the review of the literature in our previous paper.