Clinical and Biochemical Heterogeneity of Depressive Disorders

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Abstract
Indirect evidence, mostly pharmacologic, suggested a role for brain neurotransmitter amines such as norepinephrine in the production of [human] depression or mania. Clinical investigations supported this concept but also indicate that depression is probably a biochemically heterogeneous group of illnesses. There may be a clinically, biochemically and pharmacologically definable subtype of depression in which there is a disorder of norepinephrine metabolism or disposition in brain. The experimental data for this hypothesis was presented.