Taxol: Quantitative Internuclear Proton-Proton Distances in CDCl3 Solution from nOe Data: 2D NMR Roesy Buildup Rates at 500 MHz
- 1 August 1992
- journal article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 55 (8) , 1157-1161
- https://doi.org/10.1021/np50086a023
Abstract
Quantitative nmr internuclear proton-proton distance measurements obtained by observation of the initial buildup rates of nOe's in 2D ROESY spectra of taxol [1] in CDCl3 are reported. A comparison to the X-ray crystal structure of taxotere [2] is made, and the results are discussed in terms of previous studies of structure-activity relationships.Keywords
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