Dynamic observation of pulmonary perfusion using continuous arterial spin‐labeling in a pig model

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Abstract
The continuous arterial spin‐labeling (CASL) method of perfusion MRI is used to observe pulmonary perfusion dynamically in an animal model. Specifically, a respiratory‐triggered implementation of the CASL method is used with approximate spatial resolution of 0.9 × 1.8 × 5.0 mm (0.008 cc) and 2‐minute temporal resolution. Perfusion MRI is performed dynamically during repeated balloon occlusion of a segmental pulmonary artery, as well as during pharmacological stimulation. A total of three Yorkshire pigs were studied. The results demonstrate the ability of the endogenous spin‐labeling method to characterize the dynamic changes in pulmonary perfusion that occur during important physiological alterations. J. Magn. Reson. Imaging 2001;14:175–180.
Funding Information
  • NIH (RR02305)