1 kb of the lactase‐phlorizin hydrolase promoter directs post‐weaning decline and small intestinal‐specific expression in transgenic mice
- 11 April 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 342 (3) , 291-296
- https://doi.org/10.1016/0014-5793(94)80519-9
Abstract
Adult-type hypolactasia is a genetic condition making approximately one half of the human population intolerant to milk because of abdominal symptoms. The cause is a post-weaning down-regulation of the intestinal-specific enzyme lactase-phlorizin hydrolase (LPH) reducing the intestinal capacity to hydrolyze lactose. We here demonstrate that the stretch −17 to −994 in the pig LPH-promoter carries cis-elements which direct a small intestinal-specific expression and a post-weaning decline of a linked rabbit β-globin gene. These data demonstrate that the post-weaning decline of LPH is mainly due to a transcriptional down-regulation.Keywords
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