Kinetics of DNA repair synthesis in guinea-pig pancreatic slices following in vitro exposure to N-methyl-N-nitrosourethane
- 1 August 1976
- journal article
- specialia
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 32 (8) , 1055-1056
- https://doi.org/10.1007/bf01933969
Abstract
Summary In vitro exposure of guinea-pig pancreatic slices to NMUT resulted in an increase in hydroxyurea-insensitive3H-TdR incorporation into DNA; this represents DNA repair synthesis following NMUT-induced DNA damage. The kinetics of this hydroxyurea-insensitive3H-TdR incorporation suggest that the NMUT-induced DNA damage is largely repaired within 2 hours.Keywords
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