A fully regiocontrolled synthesis of desacetamidoisocolchicine: formal total synthesis of colchicine
- 1 January 1990
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 20,p. 1450-1452
- https://doi.org/10.1039/c39900001450
Abstract
The tetracyclic compound 3a, which has been synthesised in nine steps from the known cyclohexenone 6, reacts with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) to give desacetamidoisocolchicine 2 in 84% yield; the acquisition of 2 constitutes a formal total synthesis of the alkaloid colchicine 1.Keywords
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