Hepatic toxicity of nitrosourea analogues
- 1 August 1974
- journal article
- research article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 16 (2) , 363-367
- https://doi.org/10.1002/cpt1974162363
Abstract
Two patients with neoplastic diseases were treated with nitrosourea derivatives and developed chemical “hepatitis.” Serialliver scintigraphy demonstrated a shift of radioactive colloid distribution that was reversible. Pathologie changes within the hepatic architecture were typical for subacute hepatitis and persisted in spite of apparent clinical recovery.Keywords
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