PROTECTION AGAINST YERSINIA INFECTION INDUCED BY NON-VIRULENCE-PLASMID-ENCODED ANTIGENS

1 October 1985

journal article
research article
Published by Microbiology Society in Journal of Medical Microbiology

Vol. 20 (2) , 225-231
https://doi.org/10.1099/00222615-20-2-225

Abstract

Summary Specific immunity against Yersinia was induced by plasmid-encoded antigens not associated with virulence. Mice were immunised with viable bacteria from a virulence-plasmid-cured strain of Y. pseudotuberculosis. This antigenic stimulation generated specific protection against virulence-plasmid-harbouring strains of Y. pseudotuberculosis and Y. pestis, demonstrating that protection can be generated by organisms lacking plasmid-encoded virulence antigens.

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