Delayed Hypersensitivity in vitro. I. Effects of Tuberculoproteins on Tissue from Sensitive Guinea Pigs.

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Abstract
The cytotoxicity of 3 tuberculoproteins, PPD, T(NY), and C, for tuberculin-sensitive macrophages has been compared in tissue culture. All 3 tuberculoproteins had cytotoxic properties in vitro. No differences were observed between in vitro effects of each of the tuberculoproteins at any one concentration. Each tuberculoprotein had a definite observable cytotoxic and inhibitory action on tuberculin-sensitive splenic macrophages at low concentrations of 1 [mu]g/ml, but none at 0.1 [mu]g/ml. Skin test reactions in sensitized guinea pigs to the 3 tuberculoproteins gave similar results.
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