Acetylsalicylic Acid-Induced Prolongation of Bleeding Time in Healthy Men

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Abstract
Bleeding times were determined in 25 healthy men using the Thrombolette bleeding time device. The median bleeding times prior to low and high doses of acetylsalicylic acid (ASA), 245 and 230 s, were not significantly different (P = 0.12). Two hours after randomized ingestion of 0.44 and 3.96 g ASA, the median bleeding times rose to 450 and 430 s, respectively. Both increases in bleeding time were significant (P < 0.001), but the difference was not significant (P = 0.29). The maximum increase in bleeding time was estimated to occur 2.6 h after ingestion of a single low ASA dose, and 2.4 h after a single high dose. Following ingestion of 0.44 and 3.96 g ASA the bleeding time returned to basal levels within 5-6 days. Compared to the younger ones, older volunteers showed a tendency to have lower plasma salicylate levels and smaller increases in bleeding times following ASA ingestion.