Improvement in Headache Associated with Prolactinoma during Treatment with a Somatostatin Analogue: An “N of 1” Study

Publisher Website
Google Scholar
Abstract
To the Editor: We have followed with interest the results of long-term treatment of acromegaly with the somatostatin analogue SMS 201–9951 , 2 and particularly the dramatic and rapid relief of headache.3 The mechanism of the analgesic action of SMS 201–995 is unknown but is not apparently related to the fall in growth hormone levels or to tumor shrinkage. This prompted us to assess the effect of SMS on intractable headache that had been present for 12 months in a 37-year-old woman with a macroprolactinoma extending 6 mm above the sella. Her mean daily prolactin levels were 6500 mU per liter (normal . . .