ALLOTYPE SUPPRESSION OF THE RESPONSIVENESS OF ADOPTIVELY TRANSFERRED ADULT SPLEEN-CELLS INDUCED BY AFFINITY PREPARED ANTI-ALLOTYPE ANTIBODY

  • 1 January 1981
    • journal article
    • research article
    • Vol. 42  (4) , 601-610
Abstract
In an adoptive transfer assay, a form of allotype suppression is induced in adult spleen cells. Use of specific-pathogen free congenic mice, and either anti-allotype serum freed of IgM rheumatoid factor or affinity prepared antibody, helps to eliminate the possibility of a role for nonspecific factors in allotype suppression. Both memory-cell development and a conventional primary response are more susceptible to suppression than memory expression in a secondary response. Nonspecific suppressive effects on isotypes other than that of the target allotype (Ig H chain constant region) are present but are much smaller than for specific suppression.