COMPARISON OF RADIOLABELED BLEOMYCINS AND GALLIUM CITRATE IN TUMOR-BEARING MICE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 18  (3) , 276-281
Abstract
Radioiodinated bleomycin is a chemically stable radiopharmaceutical that can be prepared with high specific activity using 123I. Its pharmacokinetics were compared with those of 99mTc-, 111In-, and 57Co-bleomycin and 67Ga citrate in mice bearing a transplanted KHJJ tumor. The in vivo kinetics and stability of 123I and 57Co-bleomycin were similar: both were acceptable, although not equivalent, tags for bleomycin and, along with 67Ga citrate, both had biologic properties suitable for tumor detection. 99mTc- and 111In-bleomycin dissociated rapidly in vivo and did not represent legitimate tags for bleomycin. 111In-bleomycin may have tumor localizing properties related to its biochemical properties after the In and chelate separate in vivo. 123I is superior to 57Co or 55Co. Tumor-to-blood and tumor-to-liver ratios were higher for 123I-bleomycin than for 67Ga or 57Co-bleomycin. The nearly ideal nuclear properties of 123I should complement the biologic properties of bleomycin and lead to a useful tumor radiodiagnostic agent.

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