PLASMA LIGNOCAINE CONCENTRATIONS FOLLOWING ENDOTRACHEAL SPRAYING WITH AN AEROSOL
Open Access
- 1 September 1976
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 48 (9) , 899-902
- https://doi.org/10.1093/bja/48.9.899
Abstract
Plasma concentrations of lignocaine were measured in three groups of anaesthetized patients following spraying of the trachea and larynx with a lignocaine 10% aerosol spray. Greater venous plasma concentrations occurred in patients who were paralysed with suxamethonium. A mean plasma concentration of 0.1 μg/ml of lignocaine resulted from each 10 mg of lignocaine used in spontaneously breathing patients, and 0.15 μg/ml in paralysed patients. In individual patients a concentration 50% in excess of the mean value may occur. The use of lignocaine 100 mg as a 10% aerosol spray can be considered safe.Keywords
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