Complete suppression of haemoglobin A synthesis in haemoglobin D Los Angeles—beta thalassaemia
Open Access
- 1 July 1968
- journal article
- research article
- Published by BMJ in Journal of Clinical Pathology
- Vol. 21 (4) , 508-510
- https://doi.org/10.1136/jcp.21.4.508
Abstract
A family study is reported in which all three siblings were shown to be doubly heterozygous for haemoglobin D Los Angeles and beta thalassaemia, which resulted in a complete suppression of haemoglobin A synthesis. This demonstrates the effects of genetic interaction which occur when the genes for haemoglobin D Los Angeles and beta thalassaemia are both transmitted to the offspring. The importance of family studies in the investigation of haemoglobin abnormalities is stressed.Keywords
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