The increase in the sugar content of the spinal fluid in epidemic encephalitis led us to investigate the sugar metabolism of patients suffering from this disease by means of the blood sugar curve. This method of studying the sugar metabolism has been criticized by a number of observers. Fitz's1 careful studies have shown that all the ingested glucose may not be absorbed, and Rowe2 has abandoned the glucose curve in his studies of endocrinopathies. However, Gray3 from an analysis of 4,000 curves was able to define the limits of variation of the blood sugar after the ingestion of glucose with sufficient accuracy to indicate that information about the sugar metabolism may be obtained by this method. Alexander4 states that the sugar curve in encephalitis tends to be higher than normal and, in the single curve plotted, the sugar goes up to 240 mg. per hundred cubic centimeters at the end