Chemotherapeutic Action of Streptomycin and of Streptomycin with a Sulfone or Sulfadiazine on Tuberculosis

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Abstract
The chemotherapeutic action of streptomycin when used alone or in combination with (I) 4-amino-4[image]-n-propylaminodiphenylsulfone, (II) 4-amino-4[image]-succinimidodiphenylsulfone, or (III) sulfadiazjne was studied in exptl. tuberculosis in guinea pigs. Chemotherapeutic effectiveness (ratio of tuberculous involvement in controls and treated groups) of streptomycin alone adm. at a level of 40 mg./kg./day was 14.4. In combined therapy the chemotherapeutic effectiveness of steptomycin (20 rag./kg./ day) with I was 28.6; with II, 18.2; and with III, 14.5. Chemotherapeutic effectiveness of the sulfones alone was 3.7 for I and 1.8 for II. Sulfadiazine has only slight activity. The results indicate a therapeutic synergy.

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