Thyrocalcitonin Suppression of Hydroxyproline Release from Bone

Publisher Website
Google Scholar
Abstract
The effects of thyrocalcitonin on extracellular levels of hydroxyproline were examined in male rats (200-220 gms) in the following situations: peritoneal lavage, parathyroi-dectomy, nephrectomy and Ca-restricted diet. Periodic subcutaneous injections of thyrocalcitonin reduced total hydroxyproline removal by peritoneal lavage in both intact and parathyroidectomized animals to 80% of control values. Similar reduction in Ca and P removal was also observed. Thyrocalcitonin was also administered every 2hr. for 24 hr. to animals maintained on a Ca-free diet, some of whom were also nephrectomized. A 20% reduction in serum hydroxyproline occurred in animals treated with thyrocalcitonin. The effects on removal of hydroxyproline and Ca by peritoneal lavage were of such magnitude to suggest that the entire process of whole bone catabolism is inhibited by thyrocalcitonin. Marked effects of thyrocalcitonin in the presence of increased levels of endogenous parathyroid hormone indicate that thyrocalcitonin can block the effects of parathyroid hormone. Repeated administration of thyrocalcitonin results in an inhibition of bone mineral and collagen resorption.

This publication has 1 reference indexed in Scilit: