The administration of the GnRH antagonist, cetrorelix, to ooctye donors simplifies oocyte donation

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Abstract
BACKGROUND: We report our experience on the efficacy of a new regimen of the GnRH antagonist, cetrorelix, and recombinant FSH, Gonal‐F, for controlled ovarian stimulation in a donor oocyte programme. METHODS AND RESULTS: Six oocyte donors were commenced on Gonal‐F (150 IU) and two on Gonal‐F 225 IU daily on day 4 together with cetrorelix 0.25 mg daily on day 8 until the day of administration of hCG. Six premenopausal recipients were down‐regulated with intranasal Nafarelin 400 µg twice daily; two women with premature menopause did not require down‐regulation for synchronization between donor and recipient cycles. The median (range) of oocytes retrieved and the median (range) fertilization rates were 7 (3–13) and 50% (0–71%) respectively. With the exception of a recipient who had failed fertilization, seven recipients had two embryos transferred. The median (range) number of days of ovarian stimulation, cetrorelix administration and number of Gonal‐F ampoules administered for ovarian stimulation were 9 (7–12) days, 5 (3–8) and 18 (14–24) respectively. The clinical pregnancy rate per cycle was 50% (4/8) and one of the latter women miscarried at eight weeks gestation. Three women (37.3%) had full term deliveries. CONCLUSION: This preliminary study has shown that using a combination of cetrorelix and Gonal‐F resulted in a high pregnancy rate, reduced the duration of treatment for the donor and simplified oocyte donation.

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