Cancer in Circumpolar Inuit 1969-1988

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Abstract
The results of an international, collaborative study of cancer in Circumpolar Inuit in Greenland, Canada, Alaska and Russia are summarized. A total of 3 255 incident cancers were diagnosed from 1969 to 1988 among 85 000-110 000 individuals. Indirect standardization (SIR) based on comparison populations in Connecticut (USA), Canada and Denmark showed excess risk of cancer of the lung, nasopharynx, salivary glands, gallbladder and extrahepatic bile ducts in both sexes, of liver and stomach cancer in men, and renal and cervical cancer in women. Low risk was observed for cancer of the bladder, breast, endometrium and prostate, and for non-Hodgkin lymphoma, Hodgkin's disease, leukaemia, multiple myeloma and melanoma. Age-standardized incidence rates (ASRs) of cancer of lung, cervix, nasopharynx and salivary glands among Inuit were among the world's highest as were rates in women of oesophageal and renal cancer. Regional differences in ASRs within the Circumpolar area were observed for cancer of the cervix, lung, colon and rectum, liver, gallbladder and breast. The differences in the Inuit cancer incidence pattern to some extent reflect known variations in lifestyle, diet and other exposures, as well as implementation of cancer control measures. Future research addressing possible individual differences are needed to evaluate environmental and genetic factors in etiology and evaluate intervention studies.