Disposition kinetics of ethylene oxide, ethylene glycol, and 2‐chlorethanol in the dog

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Abstract
This disposition kinetics of ethylene oxide, ethylene glycol and 2-chlorethanol were studied following i.v. administration to beagle dogs. Plasma concentration of ethylene oxide declined exponentially with a mean constant of 0.024 .+-. 0.008/min (mean .+-. SD) and total body clearance of 20.0 .+-. 5.2 ml/kg.cntdot.min. Ethylene oxide was metabolized mainly to ethylene glycol, which had a mean plasma half-life of 221.0 .+-. 77.7 min and a total body clearance of 2.13 .+-. 0.58 ml/kg.cntdot.min. Between 7 and 24% of i.v. administered ethylene oxide was eliminated in the urine as ethylene glycol within 24 h. The elimination half-life and clearance values of 2-chlorethanol were 40.8 .+-. 5.7 min and 10.3 .+-. 1.7 ml/kg.cntdot.min, respectively. The pharmacokinetic data suggested that ethylene glycol rather than 2-chloroethanol was the major metabolite of ethylene oxide in the dog.