Synthesis and Structure−Activity Relationship Study of Lamellarin Derivatives
- 14 March 2002
- journal article
- review article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 65 (4) , 500-504
- https://doi.org/10.1021/np0104525
Abstract
Ten derivatives (3−12) of marine alkaloid lamellarin D (1) were synthesized and evaluated for cytotoxicity against a HeLa cell line in an effort to examine their structure−activity relationships. It appeared that the hydroxyl groups at positions C-8 and C-20 of 1 were important structural requirements for cytotoxic activity, while the hydroxyl group at C-14 and the two methoxy groups at C-13 and C-21 were not necessary for the activity.Keywords
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