Lithium Carbonate in Chemotherapy-Induced Neutropenia

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Abstract
To the Editor: The article on "Lithium Carbonate Attenuation of Chemotherapy-Induced Neutropenia" by Stein et al. (N Engl J Med 297:430, 1977) highlights an important principle of tumor chemotherapy that is often not well understood. Most antineoplastic agents unfortunately lack specificity and do not distinguish normal and neoplastic cells. The cytocidal action of these drugs depends largely on the proliferative state of the target cell, resting cells being relatively resistant and proliferating cells quite sensitive (Valeriote F, van Patten L: Proliferation-dependent cytotoxicity of anticancer agents: a review. Cancer Res 35:2619, 1975).A number of determinants may predict a successful . . .

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