THE HAEMOLYTIG ACTION OF PHENOTHIAZINE DERIVATIVES

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Abstract
The haemolysis of horse erythrocytes by saponin or by lysolecithin, in vitro, is powerfully accelerated in the presence of phenothiazone, thiazine S-methyl sulphonium perchlorate, and especially the urinary conjugate, potassium leucophenothiazone sulphate. Bile salt haemolysis is only slightly affected.Sheep cells are more resistant to haemolysis and to its acceleration by these derivatives.Phenothiazone does not produce photodynamic haemolysis.This acceleration of haemolysis is suggested as an explanation of the haemolytic anaemia frequently observed in some species after treatment with phenothiazine.

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