Influences of operative stress on cell‐mediated immunity and on tumor metastasis and their prevention by nonspecific immunotherapy: Experimental studies in rats

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Abstract
Influences of operative stress on nonspecific cell‐mediated immunity and on liability to tumor metastasis and preventive effects thereon of a non‐specific immunopotentiator OK‐432 were examined. Syngeneic female SD rats were inoculated SC with 200 mg of a transplantable mammary carcinoma MRMT‐1 at the dorsal flank. After 2 weeks the tumor was surgically excised simply or combined with 30‐min laparotomy. It was revealed by follow‐up examination that the laparotomy stress significantly increased incidence of postoperative lung metastasis. It was found that PHA‐induced blastogenesis of peripheral lymphocytes was markedly reduced in the early period following laparotomy. Preoperative or postoperative (especially the former) administration of OK‐432 was effective for preventing both the postlaparotomy facilitation of lung metastasis and the postlaparotomy reduction in PHA lymphoblastogenesis.