A Model for Magnetization Transfer in Tissues

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Abstract
Magnetization transfer in several tissues is measured and successfully modeled using a two-pool model of exchange. The line shape for the semi-solid pool is characterized by a superLorentzian and the liquid pool by a Lorentzian. The tissues investigated were white and gray matter, optic nerve, muscle, and liver. All tissues the authors studied are characterized by the same model but differ in the parameter values of the model. Blood and cerebral spinal fluid (CSF) were also investigated. The two-pool model with a Lorentzian line shape for both the semi-solid and liquid pools modeled the magnetization transfer in blood. In CSF, as expected, there is no measurable exchange of magnetization. The T2B associated with the semi-solid pool was short (˜10 μ) for all tissues indicating a fairly rigid semi-solid pool. In addition characterization of the line shape as superLorentzian indicates molecules such as integral membrane proteins or lipids in membranes are likely molecules participating in the exchange. Conversely, in blood large globular proteins are indicated due to the Lorentzian nature of the semi-solid pool and a T2B ≈ 300 μs.