Tumor Implantation on Colon Mucosa

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Abstract
THE high incidence of recurrence at the suture line following primary resection and anastomosis for colon carcinoma has been documented repeatedly1 since attention was directed to this problem in 1952.2 Since the observations were confirmed experimentally,3,4 a number of studies have been conducted to study techniques which might reduce the rate of recurrence.5,6 Normal, intact mucosa was reported to have an increased resistance to tumor implantation.2 It has been assumed that tumor implantation could occur on the interrupted or damaged mucosa at the suture line. However, there was no experimental work specifically designed to evaluate this premise. Recently it has been suggested that tumor implantation in the suture line may be the result of tumor cells growing through the bowel wall after the implantation on the serosal surface, or the subsequent growth of tumor cells carried into the suture line by the sutures. This study

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