Degradation of epidermal growth factor receptors by cathepsin L-like protease: Inhibition of the degradation by c-Ha-rasgene products
Open Access
- 20 June 1988
- journal article
- Published by Wiley in FEBS Letters
- Vol. 233 (2) , 367-370
- https://doi.org/10.1016/0014-5793(88)80462-9
Abstract
Extract of N1H3T3 mouse fibroblasts contains a protease which can cleave epidermal growth factor receptor (EGF receptor). This protease was tentatively named cathepsin X and purified to near homogeneity. The characteristics of cathepsin X were similar to those of cathepsin L and the proteolytic activity of cathepsin X was inhibited by c‐Ha‐ras gene products.Keywords
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