PLASMA-CONCENTRATIONS OF PYRIMETHAMINE AND SULFADOXINE AND EVALUATION OF PHARMACOKINETIC DATA BY COMPUTERIZED CURVE FITTING

  • 1 January 1982
    • journal article
    • research article
    • Vol. 60  (1) , 115-122
Abstract
For the determination of the plasma concentration profiles of pyrimethamine and sulfadoxine after the administration of 1 tablet of Fansidar, highly specific analytical methods are needed as the pyrimethamine concentration is low (0.2-0.02 mg/l and the concentration ratio of the 2 components in the plasma is high (> 1:500). The microbiological method fulfills these requirements for high specificity and sensitivity (the sensitivity limit for sulfadoxine is 1 mg/l and for pyrimethamine is 0.013 mg/l. Pharmacokinetic data were evaluated for 14 [humans] volunteers after administration of 1 tablet of Fansidar and a computer simulation of multiple dosing (1 tablet/wk) was performed.