Small-Dose Clonidine Prolongs Postoperative Analgesia After Sciatic-Femoral Nerve Block with 0.75% Ropivacaine for Foot Surgery

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Abstract
This prospective, randomized, double-blinded study demonstrated that, when providing combined sciatic-femoral nerve block for hallux valgus repair, the addition of 1 μg/kg clonidine to 0.75% ropivacaine prolongs the duration of postoperative analgesia by 3 h, with only a slight and short-lived increase in the degree of sedation and no hemodynamic adverse effects.