Radiation-Induced "Dental Death" in Mice

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Abstract
Young adult mice of the RF and LAF1 strains developed defects of the incisor teeth after exposure of the head to 1250 to 1800 r of X-rays. The time of onset of dental defects varied with the dose of radiation. All mice exposed to 1350 r exhibited changes within 70 days after exposure. Severely affected mice were unable to feed adequately on food pellets and starved to death unless provided with a soft diet. Intraperitoneal injection of 2-mercaptoethylguanidineHBr before irradiation lessened the radiation injury of tooth-forming cells.