CANINE CYCLIC HEMATOPOIESIS - EFFECTS OF CHRONIC ENDOTOXIN ADMINISTRATION

  • 1 January 1978
    • journal article
    • research article
    • Vol. 52  (6) , 1170-1177
Abstract
Endotoxin [from Escherichia coli] was given to grey collie dogs to investigate the mechanism of cyclic hematopoiesis. Over prolonged periods of daily administration, low doses of endotoxin (0.1 .mu.g/kg per day) failed to change the cycling of blood neutrophils or reticulocytes. Higher doses of endotoxin maintained at a plateau level (5 .mu.g/kg per day) eliminated the cyclic changes in neutrophils and stabilized the reticulocyte and platelet counts in the normal range. Administration of endotoxin at this dose also eliminated the cyclical marrow differential count fluctuations characteristic of this disease. Endotoxin apparently ameliorates the cyclical changes in blood cell counts by regulating hematopoietic proliferative activity at the stem cell level.