The Joint Impact of Family History of Myocardial Infarction and Other Risk Factors on 12-year Coronary Heart Disease Mortality

Abstract
We investigated the impact of family history of myocardial infarction on 12-year coronary heart disease mortality. Men and women with a family history had an increased risk for coronary heart disease death, irrespective of other risk factors (RR = 1.58; 95% CI = 1.17–2.13 and RR = 2.12; 95% CI 1.11–4.05, respectively). Women with a family history seemed to be more susceptible to the detrimental effects of smoking; not to the effects of other risk factors. We found no effect modification by family history in men. (Epidemiology 1999

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