Experimental Spinal Fusion in Guinea Pigs and Dogs The Effect of Immobilization

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Abstract
This paper describes the changes seen alter various types of operation attempted to obtain fusion of the lumbar or lumbosacral spine in experimental animals. Changes were noted not only at the site of operation but also in other parts of the vertebral arch. Similar operations were done in both the guinea pig and the dog. The results obtained were very similar in many respects. Both gross and histological observations were made to assess the results. Interest in the changes that take place after operations to obtain spinal fusion originally stemmed from observations made after anterior tusion for tuberculosis of the spine in children in East Africa.4 There has been only one publication to date of histological changes after “anterior” spinal fusion in experimental animals. This work was done by one of the authors21 and is incorporated in this paper. In describing the types of surgery done, the terms used are those commonly employed for human patients. Thus the term “anterior” is used instead of “ventral,” “posterior” instead of “dorsal” and “intertransverse” for “dorsolateral.”

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