Technique-related variation in results of FANA tests.

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Abstract
The reliability and reproducibility of 3 tests for fluorescent antinuclear antibodies (FANA) that are routinely performed in the laboratory [rheumatoid arthritis]. Sera from, 72 patients, selected according to diagnosis (SLE [systemic lupus erythematosus] in 28, RA [rheumatoid arthritis] in 12, and other connective-tissue diseases in 33), and from 32 healthy controls were tested wiht all three assays. There were wide variations between the results obtained with these tests. The variations did not reflect sensitivity or degree of standardisation (reproducibility on retesting was > 95%) and appeared to be inherent in the techniques. Clinicians should be aware of the technique-related differences in FANA assays.

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