Neuroendocrine Differentiation in Müllerian Neoplasms: An Immunohistochemical Study of a “Pure” Endometrial Small-Cell Carcinoma and a Mixed Müllerian Tumor Containing Small-Cell Carcinoma

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Abstract
Two neoplasms of the endometrium exhibiting histologic features of small cell carcinoma (SCC) were studied immunohistochemically for the presence of antigens indicative of neuroendocrine differentiation. The first case, a pure SCC, was positive for neuron-specific enolase (NSE), Leu-7, and chromogranin. The second case, a mixed miillerian tumor, had an extensive SCC component; the latter element was reactive for NSE and Leu-7. The first patient has had an unexpectedly long survival, while the second patient died with multiple distant metastases, containing only SCC.