Studies on Some Dehydrogenases in Experimental Retinal Ischaemia

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Abstract
In experimental ischaemic conditions of the rabbit retina, the activities of succinate dehydrogenase (EC 1.3.99.1), malate dehydrogenase (EC 1.1.1.37), glutamate dehydrogenase (EC 1.4.1.2), Iactate dehydrogenase (EC 1.1.1.27) and α-glycerophosphate dehydrogenase (EC 1.1.1.8) were examined histochemically. Studies were performed under ischaemic conditions as well as after restoration of the blood supply. The activity of LDH was also determined biochemically, and the LDH isoenzyme pattern was estimated. In longer periods of ischaemia, changes take place in the isoenzyme distribution of LDH. It was inferred that, between 40 and 60 min after the interruption of blood circulation, severe and irreversible changes in retinal metabolism develop.

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