Determination of α-chloralose residues in vertebrate tissues by gas-liquid chromatography
- 1 January 1984
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in The Analyst
- Vol. 109 (10) , 1335-1338
- https://doi.org/10.1039/an9840901335
Abstract
A method is described for the analysis of residues of the narcotic α-chloralose in vertebrate tissues. Following solvent extraction and gel permeation clean-up, residues are converted into the trimethylsilyl (TMS) derivative for the analysis by gas-liquid chromatography. Recoveries are greater than 65% and the limit of determination is between 0.2 and 1.0 mg kg–1, depending on the type of tissue analysed. Methods for the confirmation of α-chloralose residues using thin-layer chromatography of underivatised α-chloralose or mass spectrometry of the chloralose-TMS derivative are described.Keywords
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