DNA: Reaction with Chloroquine
- 3 September 1965
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 149 (3688) , 1111-1113
- https://doi.org/10.1126/science.149.3688.1111
Abstract
Diflerence spectrophotometry shows that double-stranded DNA produces mnarked changes in the absorption spectrum of chloroquine; only minor changes occur with single-stranded DNA. A DNA-chloroquine complex was demonstrated to sediment in the analytical ultracentrifuge. Chloroquine strongly elevated the thermal dissociation temperature, Tm, of DNA. It is concluded that the drug forms a complex with DNA by ionic interaction and stabilizes the helix.Keywords
This publication has 15 references indexed in Scilit:
- The interaction of nucleic acids with diaminesBiochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects, 1963
- Structural Studies of Heparin. I. Hydrolytic Cleavage of Sulfates*Biochemistry, 1963
- Antibodies to denatured deoxyribonucleic acid in lupus erythematosus serum. V. Mechanism of DNA-anti-DNA inhibition by chloroquineArchives of Biochemistry and Biophysics, 1963
- THE ROLE OF DEOXYRIBONUCLEIC ACID IN RIBONUCLEIC ACID SYNTHESIS, III. THE INHIBITION OF THE ENZYMATIC SYNTHESIS OF RIBONUCLEIC ACID AND DEOXYRIBONUCLEIC ACID BY ACTINOMYCIN D AND PROFLAVINProceedings of the National Academy of Sciences, 1962
- The Protective Effect of Spermine and Other Polyamines Against Heat Denaturation of Deoxyribonucleic AcidBiochemistry, 1962
- The reaction of formaldehyde with denatured DNA: Spectrophotometric, immunologic, and enzymic studiesJournal of Molecular Biology, 1962
- Structural considerations in the interaction of DNA and acridinesJournal of Molecular Biology, 1961
- The mode of action of actinomycin DBiochimica et Biophysica Acta, 1960
- Zur Wirkungsweise von ActinomycinenHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1960
- THE NATURE OF THE INTERACTION OF NUCLEIC ACIDS AND NUCLEI WITH BASIC DYESTUFFSCold Spring Harbor Symposia on Quantitative Biology, 1947