Inapparent Congenital Cytomegalovirus Infection

Abstract
Twenty-six infants born during 12 months at a general hospital had congenital cytomegalovirus infection. Clustering of cases was not apparent either by date of birth or by geographic location, suggesting that the observed attack rate of congenital infection (1.2 per cent) was not the result of a community epidemic. Clinically apparent cytomegalic inclusion disease was present in only one infected infant. The birth weight of nine infected infants was less than 2500 gm, but the occurrence of neonatal problems such as jaundice and hepatosplenomegaly was similar to that found among uninfected control infants. Mothers of infected babies were younger and more likely to be primiparas than mothers of uninfected controls. During a mean follow-up of eight months, unfavorable clinical outcome was observed in three infected infants with low birth weights and in no controls.
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