Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo
Open Access
- 1 July 2005
- journal article
- Published by Oxford University Press (OUP) in Neuro-Oncology
- Vol. 7 (3) , 236-245
- https://doi.org/10.1215/s1152851704000961
Abstract
U87MG human glioma cells in cultures expressed metabotropic glutamate (mGlu) receptors mGlu2 and mGlu3. Addition of the mGlu2/3 receptor antagonist LKeywords
This publication has 27 references indexed in Scilit:
- Malignant gliomas: perverting glutamate and ion homeostasis for selective advantageTrends in Neurosciences, 2003
- Blockage of Ca2+-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cellsNature Medicine, 2002
- Metabotropic Glutamate Receptor Subtypes as Targets for Neuroprotective DrugsJournal of Cerebral Blood Flow & Metabolism, 2001
- Glutamate antagonists limit tumor growthProceedings of the National Academy of Sciences, 2001
- Neuroprotection by metabotropic glutamate receptor agonists: LY354740, LY379268 and LY389795European Journal of Pharmacology, 1999
- Synthesis, Pharmacological Characterization, and Molecular Modeling of Heterobicyclic Amino Acids Related to (+)-2-Aminobicyclo[3.1.0]hexane- 2,6-dicarboxylic Acid (LY354740): Identification of Two New Potent, Selective, and Systemically Active Agonists for Group II Metabotropic Glutamate ReceptorsJournal of Medicinal Chemistry, 1999
- LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptorsNeuropharmacology, 1998
- Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cordNeuropharmacology, 1996
- Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunitNeuron, 1992
- RNA editing in brain controls a determinant of ion flow in glutamate-gated channelsCell, 1991