Lipase YS-catalysed acylation of alcohols: a predictive active site model for lipase YS to identify which enantiomer of a primary or a secondary alcohol reacts faster in this acylation
- 1 January 1994
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 10,p. 1253-1256
- https://doi.org/10.1039/p19940001253
Abstract
Primary alcohols having a hydroxymethyl group at an S chiral centre and secondary alcohols with an R configuration are preferentially acylated to give the corresponding acetates by lipase YS-catalysed acylation in diisopropyl ether; a predictive cubic-spaced active site model for lipase YS is proposed for identifying which enantiomer of a primary or a secondary alcohol reacts faster in this acylation.Keywords
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