Association of cell surface receptors for melanotropin with the Golgi region in mouse melanoma cells.
- 1 February 1976
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 73 (2) , 559-562
- https://doi.org/10.1073/pnas.73.2.559
Abstract
Binding of beta-melanotropin (betal-melanocyte stimulating hormone) to mouse melanoma cells occurs in a region on the cell surface overlying the Golgi complex. This association was demonstrated by labeling cells with fluorescein isothiocyanate hormone and by locating the Golgi complex with a histochemical test for thiamine pyrophosphatase activity. The biologically active fluorescent hormone appears on the surface and later in vesicles in the malanized cells, as judged by fluorescence microscopy. It is conceivable that internalization of the hormone is instrumental in the process of hormonally induced melanization. Because initial and late events of hormonally induced pigmentation are related to the Golgi complex, it is likely that instructions that follow the attachment of melanotropin to receptors are carried out in a compartmentalized manner.Keywords
This publication has 14 references indexed in Scilit:
- Melanocyte-stimulating hormone promotes activation of pre-existing tyrosinase molecules in Cloudman S91 melanoma cellsNature, 1975
- Melanoma cells resistant to inhibition of growth by melanocyte stimulating hormone.Proceedings of the National Academy of Sciences, 1975
- Cytochemical studies on golgi apparatus, GERL, and lysosomes in neurons of dorsal root ganglia in mice.Proceedings of the National Academy of Sciences, 1975
- Regulation of Melanocyte Stimulating Hormone Action at the Receptor Level: Discontinuous Binding of Hormone to Synchronized Mouse Melanoma Cells During the Cell CycleProceedings of the National Academy of Sciences, 1974
- Molecular biology of pigment cells. Molecular controls in mammalian pigmentation.1973
- INSULIN BINDING TO RAT LIVER GOLGI FRACTIONSThe Journal of cell biology, 1973
- Control of Phenotypic Expresssion of Cultured Melanoma Cells by Melanocyte Stimulating HormonesNature New Biology, 1973
- N6,O2′-Dibutyryl Adenosine 3′,5′-Monophosphate induces Pigment Production in Melanoma CellsNature New Biology, 1972
- ULTRASTRUCTURAL AND CYTOCHEMICAL OBSERVATIONS ON B-16 AND HARDING-PASSEY MOUSE MELANOMAS THE ORIGIN OF PREMELANOSOMES AND COMPOUND MELANOSOMESJournal of Histochemistry & Cytochemistry, 1968
- Role of Sulfhydryl Compounds in PigmentationScience, 1948