Induction of IgG1 and IgE responses to protein-conjugated and unconjugated β-lactam antibiotics in the mouse-efficacy of Freund's complete adjuvant

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Abstract
One or two injections two weeks apart of protein-conjugated penicillin G, cephalothin or cefmetazole emulsified with Freund's complete adjuvant were quite effective in producing anti-antibiotic antibodies of the IgE as well as of the IgG1 class in mice. Long-lasting and boostable production of both antibody classes was also obtained against unconjugated cephalothin or cefmetazole, though the positivity depended on the mouse strain.