Lipoprotein-Associated Phospholipase A 2 Is an Independent Marker for Coronary Endothelial Dysfunction in Humans

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Abstract
Objective— The purpose of the current study was to determine whether lipoprotein-associated phospholipase A2 (Lp-PLA2) is associated with coronary endothelial dysfunction and is a predictor of endothelial dysfunction in humans. Methods and Results— Patients (172) with no significant coronary artery disease (2 were measured, and patients were divided into tertiles. Patients in tertiles 2 and 3 had a significantly lower change in coronary blood flow (63.8±73.2 and 32.0±71.7 versus 78.4±73.2%; PP2 than those with normal endothelial function (246.2±71.6 versus 209±56.7 ng/mL; P=0.001). The odds ratio for coronary endothelial dysfunction in patients with Lp-PLA2 in the highest tertile was 3.3 (95% CI, 1.6 to 6.6). Conclusions— Lp-PLA2 is independently associated with coronary artery endothelial dysfunction and is a strong predictor of endothelial dysfunction in humans. Coronary endothelial dysfunction can be considered a marker for early atherosclerosis and has been shown to be associated with an increased risk of ischemic cardiac events and stroke. The results of the current study show that Lp-PLA2, an enzyme involved in the metabolism of oxidized phospholipids, is independently associated with coronary artery endothelial dysfunction and is a strong predictor of endothelial dysfunction in humans.