Transformations in glycyrrhetinic acid: rearrangement of ring A

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Abstract
Methyl 11-oxo-18 β-A-neo-oleana-3, 12-dien-30-oate and the corresponding 18α-isomer have been prepared and tested for anti-inflammatory and antidiuretic activity. Relative to methyl glycyrrhetinate, both kinds of activity and toxicity are reduced by the rearrangement. Features of interest in the nuclear magnetic resonance spectra of 18α- and 18 β-derivatives of glycyrrhetinic acid are recorded.