Effect of Reserpine Pretreatment on Stimulation of the Accelerans Nerve of the Dog
- 17 October 1958
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 128 (3329) , 901-903
- https://doi.org/10.1126/science.128.3329.901.b
Abstract
Pretreatment with two doses of reserpine (each 0.1 mg/kg, intraperitoneally) sensitizes the heart to the positive chronotropic action of norepinephrine and reduces the response to stimulation of the accelerans nerve. Ganglionic transmission remains unaffected. The results indicate that the presence of certain stores of peripheral sympathetic transmitter is essential for the production of tachycardia by stimulation of the accelerans nerve.Keywords
This publication has 2 references indexed in Scilit:
- The action of reserpine on the peripheral sympathetic systemThe Journal of Physiology, 1958
- Action of Nicotine on the HeartBMJ, 1958