PHYSIOLOGICAL INVESTIGATIONS ON THE EXCRETION OF KYNURENINE IN HUMANS

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Abstract
Concentration of kynurenine in human urine shows variations of about 16% during the day and approximately as much (13%) from day to day. The variations are not clearly related to daily urine output, specific gravity, urinary creatinine, and the presence of indican or diazo-reaction.Elimination of tryptophan from the diet leads to gradual decrease of kynurenine excretion in persons who have excreted large amounts on mixed diet, but not in persons excreting only traces. Concentration of kynurenine in urine rises after administration of tryptophan. The response to tryptophan varies widely from subject to subject. Nicotinamide seems to decrease excretion of kynurenine. No consistent effect of pyridoxine has been observed.Older persons tend to excrete higher concentrations of kynurenine. Normal adults of 20 years average age present an average level of 0.1 mgm. kynurenine per 100 ml. of urine, much of which is not true kynurenine. The average level in older persons (47 years average age) without physical disease has been found to be 0.21 mgm. per 100 ml.

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